Welcome to the Gilkes Lab
Women's Malignancy Program | Johns Hopkins School of Medicine
Our lab is part of the Breast and Ovarian Cancer Program at the Johns Hopkins School of Medicine.
Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that low oxygen tension (hypoxia), which occurs in most solid tumors, alters the biophysical and biochemical parameters of the tumor. Our work is focused on the role of hypoxia in breast cancer. One of our main interests are the particular genetic alterations that happen under hypoxia and how they can both contribute to tumor progression and be prevented. We are also investigating the role of the extracellular matrix signalling in breast cancer development, progression, and resistance to therapy. We are a dynamic and creative lab that always likes a good challenge. We address our questions through 2D and 3D
Breast & Ovarian Cancer Program
1650 Orleans Street
CRBI Room 128
Baltimore MD, 21231